Just looking around at doing a trip up to 421 The Snake up in TN. I figured I'd share the route im looking into for anyone else who hadnt heard about it.
http://www.421thesnake.com/
Greenville, SC to Marion to 80 to BRP to 226 to 261 to 19E to 37 to 321 to 67 into Mountain City, TN
https://goo.gl/maps/ieu6x
421 The Snake
https://goo.gl/maps/69mnL